BRAIN Biotech and Bonumose collaborate on enzymes for the production of rare monosaccharides
BRAIN Biotech AG, a leading European industrial biotechnology specialist, and rare sugars expert Bonumose, announced today that they have reached initial project milestones as part of their strategic collaboration. The companies aim to improve the performance of several enzymes that catalyze cascade reactions in the continuous production of low-calorie, ultra low-glycemic, naturally occurring sweeteners.
Bonumose has developed a patented process for producing tagatose and allulose which eliminates several processing steps and significantly increases yields during the production process. The company uses multiple enzymes within the synthesis cascades and BRAIN Biotech is optimizing several of these enzymes using enzyme engineering.
Patrick Lorenz, Vice President, Strategic Initiatives BioScience at BRAIN Biotech says: “BRAIN Biotech´s enzyme technology suite has proven once again to deliver on a customer´s challenging protein engineering targets. Based on rational structure- and sequence-guided design we improved individual enzymes and their cumulative performance in cascades to better match production process requirements. The ultimate aim is making production of Bonumose´s beneficial rare sugars even more cost efficient.”
Ed Rogers, Co-founder and CEO at Bonumose, states: “Tagatose and allulose have 92% and 70% the sweetness of sucrose but only 38% and 10% of the calories. Our mission is to produce them in a low cost production process from commodity carbohydrates. Our development collaborator BRAIN Biotech has passed the third milestone in the collaboration and thanks to their enzyme engineering, analytics and enzyme assay expertise we are on track and confident to meet our developmental objectives“.
About BRAIN
BRAIN Biotech AG is a leading European supplier of bio-based products and solutions such as enzymes and proteins, microbial production strains, natural compounds and biotechnological solutions for more sustainable industrial processes. The company focuses on the fields of nutrition, health and environment.
BRAIN Biotech AG is the parent company of the international BRAIN Biotech Group. The Group's business activities are divided into three segments: The BioProducts segment comprises the product business with specialty enzymes and other proteins, for which the Group operates fermentation facilities in the United Kingdom and production facilities in continental Europe and the United States. The BioScience segment offers research-intensive custom solutions based on enzyme technology, strain development, bioprocess development and natural product screening. The BioIncubator segment conducts its own R&D projects or those initiated with partners with high value-added potential. A particularly promising incubator project is the development of the Company's own CRISPR-based gene editing technology platform, which is currently being established and expanded by Akribion Genomics (in foundation planning).
Through its own R&D activities, BRAIN Biotech Group is continuously expanding its product portfolio in the field of specialty enzymes and small molecules. The latter are the starting point for screenings, e.g. for novel drug candidates for pharmaceutical applications.
BRAIN Biotech AG has been listed on the Prime Standard of the Frankfurt Stock Exchange since February 9, 2016 (ticker symbol: BNN; securities identification number: ISIN DE0005203947 / WKN 520394). The company employs approximately 330 people and generated revenues of EUR 55,3 million in the fiscal year 2022/23.
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About Bonumose
Bonumose is a growth-stage startup food ingredient and enzyme innovation company based near Charlottesville, Virginia. Bonumose is supported by global strategic investors and “food for health”-focused institutional investors, and an expanding network of global collaboration partners across the value chain. Bonumose developed and patented the methods for continuous production of high-purity tagatose from low-cost, plant-based starch. Bonumose’s process includes upcycling by-product/sidestream starch left over from its supply chain partners’ food production. Beyond food ingredients, Bonumose also is developing enzyme solutions for dietary supplements, crop protection, animal nutrition, and other globally-significant industries. Due to the global public health significance of Bonumose’s innovations, the World Economic Forum recently designated Bonumose as a “Technology Pioneer” for 2022. Bonumose operates with a philosophy of Business as a Moral Imperative.
Disclaimer
This press release contains forward-looking statements. These statements reflect the current views, expectations, and assumptions of the management of BRAIN Biotech AG, and are based on information currently available to the management. Forward-looking statements are no guarantees of future performance, and entail both known and unknown risks as well as uncertainties that could cause actual results, performance or events to differ materially from those expressed or implied in such statements. Numerous factors exist that could influence the future performance of and future developments at BRAIN Biotech AG and the BRAIN Biotech Group. Such factors include, but are not limited to, changes in the general economic and competitive environment, risks associated with capital markets, currency exchange rate fluctuations, changes in international and national laws and regulations, in particular with respect to tax laws and regulations, as well as other factors. BRAIN Biotech AG does not undertake any obligation to update or revise any forward-looking statements.