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Microorganisms & Production Strains

Microorganisms & Production Strains

We tailor your microbial strain for industrial use

We provide everything you need to find the best microorganism for your application, whether you are looking for a high-yield production strain for enzyme and protein production, a strain for the production of a valuable biomolecule, a starter culture for fermented food products, or even a probiotic. We offer the entire R&D pipeline of microbial strain development. 

Take advantage of our more than 30 years of experience in microbiology and genetic engineering and get access to microbial food ingredients and sustainable solutions.

Microbial discovery services

The BioArchive: Proprietary microbial strains

Access our collection of tens of thousands unique microbial strains

Screen in our "Explorer Collections"

Innovate by screening our Explorer Collections of so far unexplored microorganisms from special environments: plant tissue & surfaces, marine samples, animal microbiomes, extreme conditions (pH, temperature, salt, metals) and more.

Benefit from our "Value Collections"

Accelerate your R&D by accessing our Value Collections of pre-characterized microorganisms for specific applications: „Food“ for innovative fermented food and beverages and „Cleantech“ for sustainable production and recycling.

Stay compliant

All strains originate from Nagoya-compliant habitats.

Bioprospecting & screening

We search for you where it makes sense

Microbiology & sampling

Leverage our profound microbiology and sampling expertise to retrieve microorganisms and metagenomes with the desired biosynthetic potential from rationally selected environments.

Nagoya-compliant strategies

Ensure to fulfill legal requirements by relying on our Nagoya-compliant isolation strategies.

Instrumental analysis ensures goals are met

Based on our in-house instrumental analytics capabilities, we set up tailored assays to detect the strains and activities you are looking for.

Strain collection

The BioArchive: Proprietary microbial strains

Access our collection of tens of thousands unique microbial strains

Screen in our "Explorer Collections"

Innovate by screening our Explorer Collections of so far unexplored microorganisms from special environments: plant tissue & surfaces, marine samples, animal microbiomes, extreme conditions (pH, temperature, salt, metals) and more.

Benefit from our "Value Collections"

Accelerate your R&D by accessing our Value Collections of pre-characterized microorganisms for specific applications: „Food“ for innovative fermented food and beverages and „Cleantech“ for sustainable production and recycling.

Stay compliant

All strains originate from Nagoya-compliant habitats.

Bioprospecting

Bioprospecting & screening

We search for you where it makes sense

Microbiology & sampling

Leverage our profound microbiology and sampling expertise to retrieve microorganisms and metagenomes with the desired biosynthetic potential from rationally selected environments.

Nagoya-compliant strategies

Ensure to fulfill legal requirements by relying on our Nagoya-compliant isolation strategies.

Instrumental analysis ensures goals are met

Based on our in-house instrumental analytics capabilities, we set up tailored assays to detect the strains and activities you are looking for.

Microbial strain development services

Strain engineering

Specific strain improvement for your purposes

Creating strains

Leverage decades of genetic engineering expertise and ask us to create strains tailored to your industrial needs.

CRISPR-Cas like genome editing tools

Access or license our proprietary CRISPR-Cas like genome editing tool BMC (BRAIN Metagenomic Cas) to accelerate your microbial strain development.

Classical strain optimization

Optimize your strains through our smart adaptive laboratory evolution (ALE) or random mutagenesis approaches to meet complex challenges such as temperature stability, high productivity, or an extended shelf life.

Integrating better enzymes

Enhance the biosynthetic potential of your strain by integrating new enzymes from our MetXtraTM enzyme discovery platfrom.

Engineering wild-type strains

Rely on our targeted, but non-GMO self-cloning strategies to optimize your wild-type production strain.

Production strains for enzymes & proteins

We provide access to our industrial production strains

Plug & Produce

We offer our industrial enzyme & protein production strains to customers. Utilize these ready-to-use strains, plug in your genes of interest and produce your target enzyme or protein. Choose from a broad range of industrial production strains with proven high yields of enzymes and proteins based on tailored fermentation protocols:

  • Escherichia coli
  • Bacillus subtilis
  • Kluyveromyces lactis
  • Komagataella phaffii (Pichia pastoris) 
  • Aspergillus niger

Holistic approach

Profit from the close collaboration between our experienced microbiologists, strain engineers and process developers to successfully establish your production strain in a short timeframe.

Kosher & halal

We are trained in implementing process steps that adhere to kosher and halal requirements.

Production strains for biomolecules

We develop strains for the production of valuable biomolecules 

Identifiying the best strain

We will identify the best base strain for the biosynthesis of your target biomolecule in our BioArchive.

Optimizing your strain

You can hand over your own strain and we will develop it further in our labs with our technologies like our proprietary CRISPR-Cas like genome editing tool BMC. Rely on our strain and metabolic engineering know-how to identify the best strategy to bring production levels of your biomolecule to scale.

Pre-developed production strains

Choose from our pre-developed production strains and processes for your business.

Development of starter cultures & probiotics

Utilize the strength of our versatile Microorganisms

Value Collection Food

This collection includes 750+ food-grade strains derived from the finest artisanal fermented foods, plant-based raw materials, and microbiomes. Most of the strains are QPS/IDF-listed or have another documented use in the food sector. Perfect starting point for the development of innovative fermented foods and probiotics, supported by our application R&D team.

Value Collection Cleantech

This collection includes several hundred strains with special capabilities: metal dissolution and metal binding, CO2 capture and utilization, production of biopolymers and microbe-plant interactions. This collection is the basis for sustainable solutions in industrial production, recycling and agriculture.

Strains tailored to your needs

Strain engineering

Specific strain improvement for your purposes

Creating strains

Leverage decades of genetic engineering expertise and ask us to create strains tailored to your industrial needs.

CRISPR-Cas like genome editing tools

Access or license our proprietary CRISPR-Cas like genome editing tool BMC (BRAIN Metagenomic Cas) to accelerate your microbial strain development.

Classical strain optimization

Optimize your strains through our smart adaptive laboratory evolution (ALE) or random mutagenesis approaches to meet complex challenges such as temperature stability, high productivity, or an extended shelf life.

Integrating better enzymes

Enhance the biosynthetic potential of your strain by integrating new enzymes from our MetXtraTM enzyme discovery platfrom.

Engineering wild-type strains

Rely on our targeted, but non-GMO self-cloning strategies to optimize your wild-type production strain.

Production of enzymes

Production strains for enzymes & proteins

We provide access to our industrial production strains

Plug & Produce

We offer our industrial enzyme & protein production strains to customers. Utilize these ready-to-use strains, plug in your genes of interest and produce your target enzyme or protein. Choose from a broad range of industrial production strains with proven high yields of enzymes and proteins based on tailored fermentation protocols:

  • Escherichia coli
  • Bacillus subtilis
  • Kluyveromyces lactis
  • Komagataella phaffii (Pichia pastoris) 
  • Aspergillus niger

Holistic approach

Profit from the close collaboration between our experienced microbiologists, strain engineers and process developers to successfully establish your production strain in a short timeframe.

Kosher & halal

We are trained in implementing process steps that adhere to kosher and halal requirements.

Production of biomolecules

Production strains for biomolecules

We develop strains for the production of valuable biomolecules 

Identifiying the best strain

We will identify the best base strain for the biosynthesis of your target biomolecule in our BioArchive.

Optimizing your strain

You can hand over your own strain and we will develop it further in our labs with our technologies like our proprietary CRISPR-Cas like genome editing tool BMC. Rely on our strain and metabolic engineering know-how to identify the best strategy to bring production levels of your biomolecule to scale.

Pre-developed production strains

Choose from our pre-developed production strains and processes for your business.

Starter cultures & probiotics

Development of starter cultures & probiotics

Utilize the strength of our versatile Microorganisms

Value Collection Food

This collection includes 750+ food-grade strains derived from the finest artisanal fermented foods, plant-based raw materials, and microbiomes. Most of the strains are QPS/IDF-listed or have another documented use in the food sector. Perfect starting point for the development of innovative fermented foods and probiotics, supported by our application R&D team.

Value Collection Cleantech

This collection includes several hundred strains with special capabilities: metal dissolution and metal binding, CO2 capture and utilization, production of biopolymers and microbe-plant interactions. This collection is the basis for sustainable solutions in industrial production, recycling and agriculture.

Want to explore even more in microbial strain development?

At BRAIN Biotech, we are committed to delivering tailored solutions to meet your specific challenges.

If you are interested in advanced microbiology services, application testing or in the development of new solutions using microbial biomass or active microorganisms, we invite you to connect with us and explore how we can drive your developments forward. 

 

End-to-end services: from discovery to manufacturing

Hand with gloves twisting closures at a bioreactor from BRAIN Biotech Group

Have you identified the optimal strain, maximized product synthesis or enabled FTO by integrating novel enzymes?

When ready to go to production, you can leverage our proven bioprocess development capabilities and optimize both fermentation and downstream processing (DSP). 

Furthermore, we ensure a smooth scale-up to full industrial production, fully aligned with your needs.

 

Specialized Expertise

All projects benefit from extensive support

Icon for bioinformatics showing a screen with enzyme modelling
Bioinformatics & AI
as key drivers for innovative, targeted and efficient developments
Bioinformatics & AI

Key driver for targeted and efficient developments

Icon for bioinformatics showing a screen with enzyme modelling

integration of bioinformatics and AI into projects to maximize project success

A strong interaction between bioinformaticians and our scientific teams is a key element for targeted and efficient developments. We are experienced not only in working with large datasets but also in identifying the ideal approach based on limited or no prior knowledge.

Benefit from the combination of a wide array of bioinformatics and AI technologies together with a long track record of biotechnology expertise.

Holistic solutions for optimal results:

  • Tailored and targeted to your individual project by integrating scientific teams and bioinformaticians to deliver optimal results
  • Committed to identifying the ideal path by leveraging technologies ranging from physics-based bioinformatics to data science and AI
  • Regular provision of solutions based on large datasets and sparce knowledge
  • Holistic solutions enabled by a wide range of expertise from enzyme design, NGS, strain sequencing including genomics and transcriptomics to bioprocess development
Sketch of a chromatography curve as a symbol for instrumental Analysis
Instrumental Analytics
accompanies projects for precise, detailed and controlled execution
INSTRUMENTAL ANALYTICS

Support of projects for precise, detailed and controlled execution

Sketch of a chromatography curve as a symbol for instrumental Analysis

Versatile & flexibly instrumental analytics 

Our experienced team collaborates closely with yours, ensuring a seamless workflow from start to finish. Whether you need precise elemental analysis for production optimization or accurate protein quantification for process development, our in-house expertise delivers results.

Instrumental analytics at BRAIN Biotech:

  • We provide technical guidance throughout the whole project from planning to the actual method development, validation, process characterisation, target quantification, stability testing and technology transfer, e.g. to GMP-certified laboratories if required.
  • Numerous methods for various analytes already available on which to build
  • Tailored and efficient analytical method development, technical guidance, validation, documentation (SOP) and technology transfer
  • Broad instrumentation from ICP-MS to GC and HPLC for full analyte spectrum
  • Wide range of sample preparation techniques to work with complex biological matrices.
  • Our analytical team provides the necessary documentation such as SOPs to maximize the efficiency of the transfer process.
Ticked checklist as Symbol for Quality management
Quality Management
ensures compliance, risk mitigation and seamless project execution
Quality Management

Ensuring quality, risk mitigation, and seamless project execution

Ticked checklist as Symbol for Quality management

Backing-up scientists by Quality Management & Process Transfer teams

To enable our scientists to focus fully on delivering exceptional project results for our clients, they are backed up by the Quality Management & Process Transfer team, which ensures regulatory requirements are met and consistent quality is maintained.

A comprehensive set of Standard Operating Procedures (SOPs) provides the foundation for achieving project objectives and ensures reproducible and comparable results. Additionally, the Quality Management & Process Transfer team ensures that all documentation requirements are met, enabling the success of innovative projects and transfer of processes.

Quality Management & Process Transfer

  • At the start of each project, we conduct a risk analysis and pre-mortem with a team of experts, proactively identifying and eliminating potential obstacles from the outset. 
  • During project execution, we support the qualification of suppliers and the selection of raw materials, considering both their suitability and availability at production scale within the relevant regulatory framework.
  • Project-specific methods and processes are documented and made available for technology transfer to customers, external CDMOs or within the BRAIN Biotech Group. 

Explore further technology services

Enzymes & Proteins
Bioprocesses & Scale-up

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